Implanting Memories – a novel approach to study the mechanisms underlying spatial working memory.
The spiking activity underlying working memory is still a territory with more question marks than exclamation points. Novel tools in electrophysiology in behaving rodents allow to implant spatial working memorys in freely moving rodents using optogenetics, as was previously done for long term memories.
My ambition is imitating the neural processes taking place in the CA1 of the hippocampus during the delay period of a spatial working memory task, thus influencing the rodent's behavior. This will be done by in-vivo neuronal extracellular recordings and optogenetic manipulation in rodents.
I also intend to examine the spiking temporal sensitivity, meaning to quantify the maximal manipulation of the optical stimuli which can still induce memory-like behavior, and to find the minimal network activated by optical stimuli which can still induce memory-like behavior.
Research Categories: Behavioral Neuroscience, Electrophysiology, Optogenetics, Working Memory