The effects of tomosyn levels in the adult-born cells of the DG on synaptic plasticity and behavior
Tomosyn is a synaptic protein which has been shown (in-vitro) to greatly change the synaptic features of the mossy fibers (MFs) emanating from the dentate gyrus (DG), a region of the hippocampus, which is implicated in learning and memory functions.
The DG is one of the few regions in which neurons are known to be generated during adulthood, as most other neurons found in the brain have been generated during the prenatal or early post-natal periods.
My work is aimed at studying the specific effects tomosyn has in the unique subset of abGCs, both in vitro and in-vivo.
To achieve this goal we make use of viral vectors and the Cre-Lox system, followed by opthogenetic electrophysiology, and behavioral tasks which examine various forms of spatial memory, as well as anxiety and depression-like behaviors.
Research Categories: Behavioral Neuroscience, Cellular/molecular neuroscience, Cognitive neuroscience, Neurodevelopment and neurogenesis