Characterizing Diffuse axonal injury in mice suffering from mild traumatic brain injury
Victims of mild traumatic brain injury (mTBI) do not show clear morphological brain defects in conventional imaging methods, but frequently suffer from long-lasting cognitive deficits, emotional difficulties and behavioral disturbances. The degree of injury is assessed by the glasgow scale, which depends on the motor and verbal responsiveness of the patient, and his subjective experience. White matter tracts are selectively vulnerable to the impact-acceleration forces that occur during TBI, and can cause diffuse axonal injury (DAI). Diffusion tensor imaging (DTI) is a magnetic resonance imaging method, that can characterize, to a better extent, brain abnormalities in mTBI, and more specifically diffuse axonal injury. Since animal studies in this field of research are rare, I aim to examine mTBI mice with DTI method, and combine them with behavioral data, to better understand the effects of the injury, and correlate it with molecular markers of DAI.
Research Categories: Behavioral Neuroscience, Cognitive neuroscience