Diffusion MRI of neuroplasticity following complex motor learning
Neuroplasticity is the capacity of the nervous system to modify its organization as a result of a dynamic internal or external environment. These modifications occur in different levels and timescales. Structural morphological changes such as formation of new synapses, gliogenesis and changes in oligodendrocytes and myelin formation are considered long scale plasticity modifications. While the dynamic characteristics of neuroplasticity have traditionally been studied by using postmortem histological procedures, the field of 'in vivo structural imaging' is becoming a more popular alternative.
In my study we aim to create a framework for identification and localization of plasticity dynamics in the mouse brain as a result of a task with two degrees of difficulty, using non-invasive imaging techniques (magnetic resonance imaging-MRI). Our focus is on diffusion tensor imaging (DTI) which enables us to visualize and characterize white matter fasciculi and gray matter regions. These examinations were accompanied by a behavioral paradigm.
Research Categories: Behavioral Neuroscience