Shiloh Yosef

Research topic: The human genetic disorder ataxia-telangiectasia (A-T) and the DNA damage response

Research methods: Cell biology, biochemistry, microscopic imaging, proteomics

Main projects in the lab include:

  1. Identification of novel branches of the ATM-mediated DNA damage response
  2. The organization of the DNA damage response in the nervous system
  3. The origins of the cerebellar degeneration in A-T
  4. Creating animal models representing defective DNA damage response in specific tissues, with emphasis on the nervous system

Shomron Noam

Research topic: Our team focuses on the analysis of genomic sequences together with gene expression to model the regulation of gene expression during health and disease.

Research methods: Deep sequencing, microarrays, molecular and cellular biology techniques.

Main projects in the lab include:

  1. The involvement of microRNAs in astrocyte activation and inflammation.
  2. The microRNA signatures associated with mental disorders such as Schizophrenia and Bipolar disorder
  3. Molecular-imaging analysis of Post Traumatic Stress Syndrome individuals (with Prof Talma Hendler)
  4. The involvement of small RNAs in repairing Alzheimer’s diseased mice models (with Prof. Uri Ashery)

Hausdorff Jeffrey

Research topics: Gait, postural control, falls and movement disorders in health (e.g., normal, aging, maturation) and pathology (e.g., Parkinson’s disease, post-stroke, Alzheimer’s disease). Areas of focus include studies of the stride-to-stride fluctuations of gait and the factors that contribute to and regulate these changes and cognitive function-gait interactions. We investigate balance and gait on three closely inter-related planes: a) study of underlying physiology and patho-physiology; b) development of new “bio-markers” that can be used for early diagnosis, prognosis, and for quantitative tracking of disease progression, aging, and the response to therapeutic interventions (e.g., at-home monitoring) and c) development and assessment of novel interventions for enhancing balance and gait (e.g., using virtual reality, pharmacologic therapy, motor learning).

Projects in the lab:

  1. fMRI, EEG, and fNIRS imaging of balance and gait in Parkinson’s disease and aging
  2. Virtual-reality based intervention for gait and cognitive function.
  3. Freezing of gait: motor and non-motor mechanisms.
  4. Bilateral coordination of gait
  5. What cognitive abilities contribute to gait and fall risk?
  6. Long-term monitoring of gait and mobility at home
  7. Anxiety, stress, fear and their relationship to movement disorders
  8. Cognitive interventions for improving gait
  9. Genetic contributions to gait and mobility
  10. Non-invasive brain stimulation for gait and cognition

Henis Yoav

Research topic: Cancer biophysics: dynamics, organization, endocytosis, and recycling of receptors and signaling proteins that regulate cell proliferation and cancer.

Research methods: Quantitative fluorescence microscopy imaging, quantitative FRAP (Fluorescence Recovery After Photobleaching) and diffusion analysis in live cells, FRAP beam-size analysis to determine membrane binding/unbinding of non-integral membrane proteins, single molecule imaging (diffusion and oligomerization studies), membrane protein interactions in live cells by patch/FRAP and by fluorescence correlation spectroscopy, quantitative endocytosis rate and recycling studies.

Projects in the lab include:

  1. Role of transforming growth factor-b (TGF-b) receptors oligomerization and endocytosis in the negating effects of TGF-b in cancer.
  2. Trafficking and signaling of bone morphogenetic protein (BMP) receptors: molecular motifs and regulatory interactions.
  3. Biophysical studies on the interactions of lipid-anchored oncoproteins (Ras and Src) with cell membranes and focal adhesions, and their roles in signaling and transformation.

Lotem Arnon

Research topic: Behavioral Ecology, Learning Evolution

Research methods: Animal experiments (birds in large aviaries or in the field) and computer simulations

Main projects in the lab include:

  1. Learning and decision making in frequency dependent games
  2. Evolution of individual and social learning
  3. Models of cognitive evolution

Elroy-Stein Orna

Research topic: Elucidating the molecular mechanisms of myelin formation and maintenance in the CNS using a mouse model for Vanishing White Matter (VWM) disease; Differentiation of stem cells to the neuronal lineage; Translational control in learning and memory; Translational Control of Gene Expression in Health and Disease.

Research methods: Molecular and Cellular Biology, Biochemistry, Immuno-histochemistry, Confocal & Electron Microscopy; Behavioral studies, MRI, Stem Cells Biology, DNA microarrays and quantitative Real-Time PCR.

Main projects in the lab include:

  1. Differentiation of Embryonic Stem Cells to myelinating cells
  2. Development of a drug for the treatment of Vanishing White Matter disease
  3. Effect of stress on myelin maintenance
  4. Translational control in Learning and memory

Avraham Karen

Research topic: Characterization of genes in the human deaf population and corresponding mouse models; the regulation by microRNAs in the auditory and vestibular systems and their targets; networks of genes and proteins in the auditory system using transcriptomics and proteomics; the correlation between anxiety and balance defects in mouse models.

Research methods: Deep sequencing/massively parallel sequencing, gene cloning, quantitative RT-PCR, immunofluorescence, yeast two-hybrid assays, cell culture, scanning electron microscopy, mass spectrometry, in situ hybridization, bioinformatics.

Main projects in the lab include:

  1. Discovery and characterization of genes for inherited hearing loss in humans using deep sequencing technology
  2. microRNA regulation in the auditory and vestibular systems and link to deafness
  3. Identification of microRNA targets in the mammalian inner ear
  4. Characterization of mouse models for human forms of deafness
  5. Gene therapy in a loxP-cre connexin 26 mouse model for human deafness
  6. The search for biological networks of hearing: a transcriptomics and proteomics approach

Beeri Michal

Research topic: the center covers basic and clinical research on diseases of the brain. Particular interest in cognitive aging and Alzheimer’s disease.

Research methods: Animal models, PCR, ELISA, Western Blot analysis, Immunohistochemistry and image analysis, Cell culture,   Animal Behavioral tests and clinical research (epidemiology, neuroimaging, clinical trials).

Projects in the lab include:

  1. Effects of dietary AGEs products on Alzheimerʼs Disease neuropathology.
  2. Effect of 9 cis β- carotene on Alzheimer’s Disease neuropathology.
  3. Pathways by which antipsychotic drugs increase weight.
  4. Effects of diabetes medications on brain gene and protein expression in Alzheimerʼs mice model.
  5. BBB permeability (in the context of brain tumors and of Alzheimer’s disease- in vitro and in vivo studies).
  6. Umbilical cord blood and neural regeneration in Parkinsonʼs and Alzheimerʼs mice.
  7. RNA methylation in aging and dementia.

Clinical research:

  1.  The Israel Diabetes and Cognitive Decline (IDCD) study- a large scale longitudinal study of initially non-demented diabetic elderly who are examined for cognition, genetics, inflammation, and life style.
  2. The Israel Registry for Alzheimer’s Prevention (IRAP)- a large scale longitudinal study of offspring of Alzheimer’s disease patients who are examined for cognition, genetics, inflammation, life style, structural and functional MRI, and LPs for Abeta 40-42, total tau and P tau.
  3. The Israel Ischemic Heart Disease Oldest Old (IIHD-OO) study- we are examining for dementia and movement disorders the 500 survivors of the IIHD, who now average 94 years of age and for whom we have data on directly assessed cardiovascular functioning in midlife.
  4. Several ongoing studies using neuroimaging (fMRI, structural MRI, DTI, and a novel BBB MRI technique) including populations with schizophrenia, ADHD, TBI, obesity, age-associated cognitive impairment, PD.

Eisenberg Eli

Research topic: RNA editing, rhythmic expression patterns

Research methods: Bioinformatic, computational. Usually in collaboration with experimentalists.

Main projects in the lab include:

  1. A-to-I RNA editing of miRNAs
  2. A-to-I editing of repetitive elements
  3. Light induced and circadian genes (in Zebrafish and other model organisms)
  4. Altered editing in neurological disorders
  5. Extra-ordinary proteome recoding by editing in cephalopods