מרכז לחדשנות בלמידה

Innovative Learning Center

מדע - תעשייה - חדשנות

Science - Industry - Innovation

Cohen-Armon Malka

Research topic: Molecular mechanisms implicated in long-term memory

Research methods: Electrophysiology, Biochemistry, Cell biology and Molecular biology, including ChIP assay, RT-PCR, FACS, confocal microscopy and behavioral tests.

Main projects in the lab include:

  1. PARP1 mediated immediate early gene expression implicated in long term memory.
  2. PARP1-ERK2 interaction in the nucleus
  3. Memory erasure by PARP inhibitors, possible implications in addiction and PTSD.

Eldar-Finkelman Hagit

Research topic: Signal transduction mechanisms in molecular metabolism, evolution, and CNS disorders.

Research methods: Cell biology, molecular biology, enzymology, protein biochemistry, live cell imaging, in vivo models, bioinformatics.

Projects in the lab include:

  1. Lysosomal regulation in neurons and neurodegeneration
  2. Biochemical and physiological aspects of the protein kinase GSK-3
  3. Development of GSK-3 inhibitors: drug design and implications in in vivo models
  4. Nuerogenesis in the bird model
  5. The cross-talk between metabolic pathways and neurodegeneration

Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) Neurodegenerative disease – Alzheimer’s disease and Parkinson’s disease 2) Stress condition –stroke. 3) Autoimmune disease – Multiple sclerosis.

Research methods: Cellular biochemistry; confocal microscopy; molecular biology; histology, immunological asses, cell culture; disease models in mice

Main projects in the lab include:

  1. Targeting the role of microglia activation in Alzheimer’s Disease.
  2. Understanding pathological changes in astrocytes–endothelial cells that link to cerebrovascular diseases
  3. Targeting the neuroprotection role of astrocyte following Stroke
  4. Understanding mechanisms of neuroinflammation in multiple sclerosis