Research topic: Ras and small GTPases signaling in the control of normal and diseased cells and tissues. Design and preparation of Ras inhibitors to inhibit cancer and autoimmune diseases including multiple sclerosis and diabetes .
Research methods: Cell biology and tissue culture, biochemistry, molecular biology, drug modeling, design and synthesis, immunology, Immunohistochemistry, proteomics, genomics, fluorescent microscopy, total Internal Reflection Fluorescence (TIRF), animal models for cancer, animal models for multiple sclerosis, for diabetes type 1 and type 2, and for stroke.
Main projects in the lab include:
- Elucidating the mode of Ras and small RNAs transfer from cell- to-cell in the immune system and in cancer
- Mechanism of the formation of Ras nanoparticles (rasosomes) and their function in Ras signaling
- The Ras-like Rheb protein and its function in the rare diseases LAM and tuberosclerosis
- Preclinical studies with novel Ras inhibitors, analogs of FTS (salirasib), for potential clinical use