Research topic: Characterization of genes in the human deaf population and corresponding mouse models; the regulation by microRNAs in the auditory and vestibular systems and their targets; networks of genes and proteins in the auditory system using transcriptomics and proteomics; the correlation between anxiety and balance defects in mouse models.
Research methods: Deep sequencing/massively parallel sequencing, gene cloning, quantitative RT-PCR, immunofluorescence, yeast two-hybrid assays, cell culture, scanning electron microscopy, mass spectrometry, in situ hybridization, bioinformatics.
Main projects in the lab include:
- Discovery and characterization of genes for inherited hearing loss in humans using deep sequencing technology
- microRNA regulation in the auditory and vestibular systems and link to deafness
- Identification of microRNA targets in the mammalian inner ear
- Characterization of mouse models for human forms of deafness
- Gene therapy in a loxP-cre connexin 26 mouse model for human deafness
- The search for biological networks of hearing: a transcriptomics and proteomics approach