Ronen Weiss Lavi, Ph.D.

Former student at Prof. Joab Chapman's laboratory

Research title
Central nervous system manifestations in Antiphospholipid syndrome.


Research project

The antiphospholipid syndrome (APS) is an autoimmune disorder, manifested by thromboembolic events, recurrent spontaneous abortions, thrombocytopenia and elevated titers of circulating antiphospholipid auto- antibodies. Neurologic disorders are among the most common and important clinical manifestations associated with the syndrome. We hypothesize that antibodies can access the brain and play a role in the neurological manifestations observed in APS patients. In order to investigate this hypothesis we work with a mouse model and cell cultures and a varity of methods including: Molecular, Histological an Behavioral exams.


Meetings

  • Weiss R, Bitton A, Elgart M, Nahary L, I, Benhar I, Blank M, Chapman J. “Autoimmunity Annxein and Anxiety”, 10th International congress on autoimmunity, Leipzig, Germany, 2016.

  • Frauenknecht K, Weiss R, Sabag A, Katzav A, Chapman J, Sommer CJ ."A reduction in hippocampal synaptopodin immunoreactivity in the experimental antiphospholipid syndrome mouse model". Oral presentaion . The Annual Israel Society of neuroimmunology conference, Mitzpe Ramon, Israel, December 2013.

  • Weiss R, Lifshitz V, Frenkel D. "Deficiency in endothelial-macrophage interaction may result in crebrovascular amyloidosis". Poster presentation, The Annual Israel Society of neuroimmunology conference, Jerusalem , Israel, April 2011.

  • Weiss R, Lifshitz V, Frenkel D."TGF-β1 affect endothelial cells cross-talk with peripheral immune response and leads to cerebrovascular amyloidosis".Oral presentation, the 19th Annual Meeting of Israel Society for Neuroscience, Eilat, Israel, December 2010.


Publications

  • Weiss R, Bitton A, Elgart M, Elhaik Goldman S, Nahary L, Cooper I, Benhar I, Chapman J. “Autoimmunity, annxein, anxiety and depression”, Journal of autoimmunity, 2016

  • Weiss R, Bitton A, Nahary L, Arango MT, Benhar I, Blank M, Shoenfeld Y, Chapman J. “ Cross reactivity between Annexin A2 and Beta 2 glycoprotein I in animal models of antiphospholipid syndrome”, Immunologic research, 2016

  • Bushi D, Gera O, Kostenich G, Shavit-Stein E, Weiss R, Chapman J, Tanne D. "A novel histochemical method for the visualization of thrombin activity in the nervous system" , Neuroscience 2016

  • Inbar R, Weiss R, Tomljenovic L, Arango MT, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. " Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil", ”, Immunologic research, 2016

  • Frauenknecht K, Katzav A, Weiss Lavi R, Sabag A, Otten S, Chapman J, Sommer CJ. "Mice with experimental antiphospholipid syndrome display hippocampal dysfunction and a reduction of dendritic complexity in hippocampal CA1 neurons". Neuropathol Appl Neurobiol. 2014 Sep

  • Lifshitz V, Weiss R, Levy H, Frenkel D. "Scavenger receptor A deficiency accelerates cerebrovascularamyloidosis in an animal model". J Mol Neurosci. 2013

  • Lifshitz V, Benromano T, Weiss R, Blanga-Kanfi S, Frenkel D."Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model". Brain Behav Immun. 2013

  • Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W , Wyss-Coray T, Weiner HL , Frenkel D. "Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model " Neurobiol Aging 2012

  • Weiss R, Lifshitz V, Frenkel D. “TGF-β1 affects endothelial cell interaction with macrophages and T cells leading to the development of cerebrovascular amyloidosis. Brain Behav Immun. 2011


Awards

  • Tel Aviv University Global Research & Training Fellowship in Medical and Life Sciences (GRTF) – Feb 2014.


Contact
ronenwei@post.tau.ac.il


Research Categories: Behavioral Neuroscience, Brain Disorders, Cellular/molecular neuroscience