Exosomes based therapies for neurodegenerative, neuropsychiatric and brain trauma disorders.
Molecular communication between cells is a fundamental biological mechanism. Numerus types of cells communicate via the secretion of small Nano-vesicles, such as exosomes, containing genetic information. The content and properties of the exosomes are dependent in their origin cell. Mesenchymal stem cells are adult stem cells that have proven to have several therapeutic abilities and are used in the Clinique in human trial. We found that exosomes secreted from mesenchymal stem cells can target damaged areas in the brain. Those exosomes present natural ability to migrate to the specific damaged areas in different pathologies such as stroke, Alzheimer, Parkinson's, autism traumatic brain injury and more.
Furthermore, except of their remarkable ability of migration, autistic mice (BTBR) that were treated with exosomes for a week, via intranasal administration, presented Signiant behavioral improvement in social interaction, vocal communication and other autistic related behaviors. We also found that in Alzheimer mice model (5xfad) treated with exosomes presented significant improvement in learning and memory.
To date, we are studying the migration abilities as well as the therapeutic potential of mesenchymal stem cells derived exosomes in several mice models.
Oral presentation at ISBP 2017 Israel.
Poster at BIRAX 2016 Oxford.
Poster at IBT 2017 Israel.
Poster at ISFN 2015 and 2016 Israel.
Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, London M and Offen D. (2017). Long Term Beneficial Effect of Neurotrophic FactorsSecreting Mesenchymal Stem Cells Transplantation in the BTBR Mouse Model of Autism. Behavioural Brain Research. http://doi.org/10.1016/j.bbr.2017.03.047
Weiner B, Hertz S, Perets N, & London M, (2016). Social Ultrasonic Vocalization in Awake Head-Restrained Mouse, 10 (December), 1–10. http://doi.org/10.3389/fnbeh.2016.00236
Betzer O, Perets N, Offen D and Popovtzer R. (2017) Real-time neuroimaging of exosomes using gold nanoparticles (In subbmition)
Perets N, Hertz S, London M and Offen D. (2017) Intranasal administration of exosomes derived from mesenchymal stem cells improves autistic-like behaviors of BTBR mice (in submmision)
Fellner A, Barhum Y, Angel A, Perets N, Steiner I, Offen D and Lev N. (2017)Toll-like receptor-4 inhibitor TAK-242 attenuates disease progression in amyotrophic lateral sclerosis mouse model (in submission)
Research Categories: Cellular/molecular neuroscience, Translational research