Investigating potential markers for targeting CNS-infiltrating monocytes
Two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory monocytes, play important roles in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Recent studies demonstrate a strong correlation between the accumulation of the inflammatory monocytes in the central nervous system (CNS) and disease severity, suggesting that targeting the CNS-infiltrating monocytes might have a therapeutic potential. Yet, there is limited information on the mechanisms that regulate monocytes infiltration into the CNS parenchyma, and of clear molecular targets that will distinguish the monocytes from the resident microglia cells.
My goal is to find a unique marker that will target infiltrating monocytes in the course of EAE and to determine the therapeutic potential of targeting these cells.
Research Categories: Immunology, Neurodegenerative disease, Neuroimmunology