Elucidating the role of microRNAs regulation in mitigating Alzheimer's disease pathology following exposure to environmental enrichment
Exposure to enriched environment (EE) has been shown to have protective effect in mice as well as in human subjects, by slowing Alzheimer's disease (AD) progression and reducing AD-like cognitive impairment. Possible underlying mechanism has been suggested to involve changes in microRNAs and synaptic proteins. However, a complete understanding of the mechanistic effects of EE on microRNAs, mRNAs, proteins expression and its rescue mechanism in AD is still missing. Furthermore, the therapeutic potential of microRNA manipulation in AD patients has never been tested.
In my research I aim to identify specific AD-progression biomarkers in a AD mouse model exposed to EE, to search for putative microRNAs that are altered after EE and to characterize the molecular, physiological and behavioral consequence of treatments with those microRNA.
Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models. Barak B1, Shvarts-Serebro I, Modai S, Gilam A, Okun E, Michaelson DM, Mattson MP, Shomron N, Ashery U. Transl Psychiatry. 2013 Sep 10;3:e304. doi: 10.1038/tp.2013.77.
2013: Teva Nateonal Network of Exellence in Neuroscience (NNE) award for PhD students.
2007: BSc in Chemical Engineering in the Technion with excellence – Cum Laude.
2000: First prize in Chemistry Olimpiada (Chimieda) – Technion.