Astrocytes’ Role in the Progression of Brain Tumors.
Glioblastoma (GBM) is one of the most aggressive solid tumors, and its grim prognosis has not changed much in the past 40 years. Astrocytes participate in diverse neurologic disorders by promoting or resolving the underlying pathologic processes and, importantly, reactive astrocytes surround brain tumors. However, little is known about the mechanisms by which astrocytes regulate tumor growth and shape the tumor microenvironment in-vivo, especially with regards to the mechanisms that regulate astrocyte activity. We aim to generate a novel dynamic model of astrocyte activation in brain cancer, and to identify new circuits by which astrocytes control GBM progression as potential immunotherapeutic targets.
Research Categories: Immunology, Neurodegenerative disease, Neuroimmunology