Micro strokes are present in the aged and injured human brain. Their clinical relevance is controversial, with postulated complications ranging from cognitive impairment to vascular dementia. Micro-strokes affect all components of the neurovascular unit (NVU), including endothelial, glial and neuronal cells.
By inducing a focal photo-thrombotic occlusion of a single penetrating artery in mouse cortex, I aim to understand the brain’s response to micro-strokes, the resultant changes in the blood brain barrier (BBB) and post-stroke cortical reorganization through time, by using two-photon microscopy and DTI.
Brain, Berlin, Germany, 2017
Oral presentation: Single penetrating artery occlusion leads to widespread white matter reorganization across the entire brain in a CX3CR1 dependent manner.
Israel society for neuroscience, Eilat, Israel, 2015