Post-Doc/PhD position in bioinformatics study of RNA editing in the brain

Published by: Eli Eisenberg

E-mail address: elieis@post.tau.ac.il

I am looking for a talented computational biologist for a postdoctoral/doctoral position in my lab.
The main focus of my bioinformatic group is RNA editing, a process upon which mRNA is enzymatically modified from its genomic blueprint. I am looking for an excellent candidate to take part in an exciting new project, where we study the extent of this phenomenon in cephalopods. As we've shown in recent years (see attached paper, for example), these species utilize RNA editing to an unprecedented level – over half of their proteome may be modified by editing!

We utilize extensive RNA-seq experiments, and work in a close collaboration with a leading experimental group in the US, which study the physiological implication of the editing events, in particular their effect of the organism neurobiology. It is possible to combine experimental work (in the US lab) with the computational project.

Please email me if you're interested.

Eli Eisenberg
Tel-Aviv University
elieis@post.tau.ac.il

Field of research: computational neuroscience

Additional information is available in this file

Laboratory website link

Join us to understand the neuronal and molecular basis of severe epilepsy and autism

Published by: Moran Rubinstein

E-mail address: moranrub@post.tau.ac.il

The tremendous advancement in genetic studies helped to identify the involvement of many genes in the etiology of autism and epilepsy. Indeed, mutations in multiple types of voltage-gated sodium channels (Nav) channels were identified in patients. In order to understand how genetic mutations in ion channels lead to altered behavior, we use mouse models that mimic the human genetic mutation and explore perturbations of neuronal function on cellular, network and behaving animal levels.
For more information please contact Moran Rubinstein: moranrub@post.tau.ac.il

Field of research: behavioral Neuroscience, brain disorders, cellular / molecular neuroscience

Additional information is available in this file

Laboratory website link

Join us at Sheppes Emotion & Self Regulation lab

Published by: Gal Sheppes

E-mail address: sheppes@post.tau.ac.il

Join our lab!
The Emotion & Self Regulation Lab seeks to integrate basic and applied science in order to study the underlying mechanisms of emotion regulation and self-regulation among healthy and clinical populations.

Open positions: Project for Sagol B.Sc students
Rotation for Sagol M.Sc students
Ph.D or Post-doc students

For more details and applying please read the attached pdf and contact our lab manager Leemor at leemorzucker@mail.tau.ac.il

Field of research: behavioral Neuroscience, cognitive neuroscience

Additional information is available in this file

Laboratory website link

Motor cognition lab

Published by: Roy Mukamel

E-mail address: rmukamel@tau.ac.il

The motor cognition lab is seeking highly motivated students and post-docs interested in the neural representation of motor actions in humans.
Using NeuroImaging (fMRI, EEG, ECoG), behavioral measures, and advanced analysis tools, we study the neural mechanisms underlying the representation of action goals ('I want to drink a cup of water'), their motor implementation ('reach the cup with my left hand since my right hand is occupied'), and expected sensory consequences ('is it water or Vodka?'). We also study the process of learning new skills (e.g. typing on a keyboard) and the influence of sensory feedback (visual, tactile, auditory) on the learning process.
Our studies bear relevance to healthy adults, expert populations (e.g. musicians and athletes), and also the rehabilitation process of patients with motor deficiencies.
Students with diverse background are welcome to apply, Previous programming/computational experience are an advantage.

Field of research: behavioral Neuroscience, cognitive neuroscience, system neuroscience

Additional information is available in this file

Laboratory website link

The Nathan Dascal’s lab is seeking for enthusiastic, motivated graduate students and postdocs.

Published by: Nathan Dascal

E-mail address: dascaln@tauex.tau.ac.il

The Nathan Dascal’s lab is seeking for enthusiastic, motivated Ph.D. students and postdocs. We investigate how hormones, neurotransmitters and drugs regulate the function of cardiac cells and neurons in health and disease, by acting on ion channels and neurotransmitter receptors.
For additional details, visit: http://medicine.mytau.org/dascal/
● Molecular and neuronal mechanisms of bipolar disorder (BPD) and related drug actions.
● Mechanisms of regulation and function of Ca2+ channels.
● Mechanisms of disease caused by dysfunction of GIRK K+ channels.
All projects involve a multidisciplinary approach that combines electrophysiology, biophysics, advanced biochemistry, fluorescent microscopy, cytochemistry, and mathematical and structural modeling. Studies are done in cultured immortalized cells, cardiomyocytes, brain slices and heterologous models.
Send C.V. to Prof. Nathan Dascal at dascaln@post.tau.ac.il, or call 03-640-5743

Field of research: brain disorders, cellular / molecular neuroscience

Additional information is available in this file

Laboratory website link

Elucidating the underlying mechanisms that drive autoimmunity and neurologic diseases – Open positions

Published by: Lior Mayo

E-mail address: lior.mayo@gmail.com

What role do glia cells play in autoimmunity? How do different cells behave during neuroinflammation? How does cellular metabolism regulate immune potential? Do lipids shape the immune response? How do peripheral immune cells, glial cells and neurons communicate? Do you want to discover how to harness the power of the body’s own immune system to help develop new treatments for Multiple Sclerosis, Alzheimer’s disease, Stroke, Brain tumors and many other illnesses?

Interested in these questions? Come and work with us in an interdisciplinary environment as we strive to elucidate the underlying mechanisms of autoimmunity and neuroinflammation. Apply state of the art experimental techniques including advanced immunologic procedures, bulk and single-cell RNA-sequencing, in-vivo imaging, real-time bioenergetic analysis, targeted and untargeted molecular imaging, mass spectrometry and more. Use in-vitro platforms, animal models and human samples to study these questions, and generate new insights leading toward a greater understanding of neuroimmunology.

Field of research: brain disorders, cellular / molecular neuroscience

Additional information is available in this file

Laboratory website link

Uncovering the dynamic nature of procedural memories – Open positions

Published by: Nitzan Censor

E-mail address: censornitzan@post.tau.ac.il

Our lab at Tel-Aviv University is seeking highly motivated students and post-doctoral fellows, to engage in exciting multidisciplinary research in human perceptual and motor learning and memory.

The overall mission of the research is to investigate the link between the way by which memories are formed, modified and internally represented and the resulting perceptual and skill learning. To achieve our research goals, we are using a multimodal approach combining behavioral psychophysics, non-invasive brain stimulation, and neuroimaging techniques.

Enthusiastic candidates with backgrounds in either Neuroscience, Psychology, Physics, Computer Science or Engineering, with excellent collaboration skills, capable of setting up and leading novel research directions are encouraged to contact Dr. Nitzan Censor at censornitzan@post.tau.ac.il and attach a statement of research interests and a CV.

Field of research: behavioral Neuroscience, cognitive neuroscience, computational neuroscience, system neuroscience

Additional information is available in this file

Laboratory website link

We are looking for enthusiastic PhD and MSc students!

Published by: Yoni Haitin

E-mail address: yhaitin@post.tau.ac.il

Our lab is interested in the effects ion channels have of the activity of immune, cancer and neuronal cells.

Ion channels are membrane-embedded molecular machines that enable cells to communicate with the extracellular world. In the immune system, microglial cells, the macrophages of the brain, express a variety of ion channels, which ignite and mediate cellular responses. However, microglial activation can be a double-edged sword, exacerbating acute brain pathologies including stroke, and neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.
Moreover, due to their newly discovered roles in cell-cycle regulation, ion channels gain increasing attention as prominent targets for cancer therapy.

Our research focuses on how anion selective channels, one of the least understood families of ion channels, contribute to brain function and immune response, and regulatory mechanisms of cancer-associated channel mutants. Using a combined multifaceted approach, which includes structural, electrophysiological and fluorescent techniques, we decipher the molecular mechanisms governing the activity and regulation of anion channels, and explore how they contribute to normal and pathophysiological microglial function.

For more information please contact Yoni Haitin: yhaitin@post.tau.ac.il

Field of research: brain disorders, cellular / molecular neuroscience, neurodevelopment and neurogenetics

Additional information is available in this file

Laboratory website link

Open positions – Lederkremer lab

Published by: Gerardo Lederkremer

E-mail address: gerardo@post.tau.ac.il

Molecular mechanisms of protein misfolding, ER stress and neurodegenerative disease

• Mechanisms of targeting and retrotranslocation in ER-­associated degradation (ERAD)
• Mechanisms of generation of ER stress in neurodegenerative disease
• Development of a novel therapy for Huntington’s disease

Highly motivated students should contact:
Gerardo Lederkremer
gerardo@post.tau.ac.il , 03-­640-­9239
http://www.tau.ac.il/~gerardol/
https://en-­lifesci.tau.ac.il/profile/gerardo

Field of research: brain disorders, cellular / molecular neuroscience

Additional information is available in this file

Laboratory website link