Leitner Yael

Research topic:

Neurodevelopmental outcome of at-risk newborns/children

ADHA

Liat Ben-Sira (Beinart)

Research topic:

  • Fetal M.R.I.
  • Brain malformation-neuro-development follow-up

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof. Dafna Ben-Bashat
  • Prof. Yaniv Assaf

Barak Boaz

Research topic:

  • Neurobiology of genetic neurodevelopmental disorders such as Williams syndrome and autism spectrum disorders.
  • Dissecting neural circuits and brain regions’ roles in anxiety-like and social behavior.
  • Therapeutic approaches to improve behavioral abnormalities in mouse models for psychiatric disorders.

Research  methods:

  • Molecular and cellular biology
  • In vivo optogenetics and pharmacogenetics
  • Behavioral tests
  • Stereotaxic surgical techniques for gene delivery
  • Nucleic acid methods
  • Transgenic and conditional knockout mouse models
  • Histology and microscopy
  • In vitro cell-based assays

Projects in the lab include:

  • In vivo optogenetic manipulation of social behavior abnormalities in mouse models for psychiatric disorders
  • Gene-rescue treatments to restore behavior and physiology in mouse models for psychiatric disorders
  • Defining the postnatal developmental and functional roles of genes in mouse models for psychiatric disorders
  • Pharmacological and pharmacogenetical studies to treat psychiatric disorders
  • Neuron-glia interactions and their role in the pathophysiology of psychiatric disorders
  • Production and characterization of novel mouse models for genetic neuropsychiatric disorders

Tamara Shiner

Research topic: Lewy body dementia (DLB) and relationship to mutations in the GBA (glucocerebrosidase) gene, Identification of early markers of neurodegeneration among first degree relatives of patients with Lewy body dementia.

Main projects in the lab include:

  1. Clinical, genetic and neuropsychological assesment of patients with Lewy body dementia and their first degree relatives.
  2. Functional and structural imaging of patients and first degree relatives of patients with Lewy body dementia.

Ast Gil

Research topic:

  • Familial Dysautonomia (FD) is a neurodegenerative disease
  • Developing new drugs to treat FD

Research  methods:

  • Generating transgenic mouse for FD
  • Drug development
  • Molecular pathways leading to neuro-degeneration

Projects in the lab include:

  • How PS (and other drugs) resulted in recovery of axonal outgrowth and enhanced retrograde axonal transport
  • Developing novel methods to deliver drugs to the brain
  • Identify the molecular pathway that leads to neurodegeneration in FD

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof. Eran Perlson

Inzelberg Rivka

Research topic: Movement disorders, Parkinson’s disease, Dementia, Genetics of Parkinson’s disease, Motor control

Research methods: Clinical research on brain disorders, Epidemiology, Motion analysis

Projects in the lab include:

  1. Melanoma and Parkinson’s disease
  2. Motor control and hand movements in Parkinson’s disease
  3. Genetic forms of Parkinson’s disease

Elkon Rani

Research topic:

Our research focuses on understanding mechanisms of gene regulation. We aim at elucidating, using bioinofrmatic methods and analysis of various omic datasets, how gene expression is regulated at the layers of transcription, stability and translation, and at discovering how interruptions in these regulatory mechanisms contribute to the development of human pathological conditions.

Research methods: Bioinformatics; systems biology; omics data obtained by various deep-sequencing techniques

Projects in the lab include:

  1. Elucidate mechanisms that regulate gene expression at the layers of transcription, transcript stability and protein translation.
  2. Identify key regulatory modules that dictate cell fate in the CNS.
  3. Elucidate the effect of genetic risk variants for brain diseases on gene regulation

Moshaiov Amiram

Research topic: Computer-supported assessments of biological systems including aspects such as: adaptation (evolution, development, life-long learning), behavior, and cognition

Research methods: Computational intelligence methods such as evolutionary computation, artificial neural-networks, fuzzy logic, and their hybridizations.

Main Projects in the lab include:

  1. Neuro-fuzzy Inferencing about Natural Systems – The development of a novel adaptive-neuro-fuzzy inference method for understanding the behavior of biological systems. In collaboration with Prof. Amir Ayali, we have already shown the effectiveness of this generic approach for the case of a marching locust in a swarm.
  2. Multi-payoff Games – In the past utility-based game theory has been used for the understanding of natural systems. In collaboration with Dr. G. Avigad and others, we have developed a non-utility based approach to multi-payoff games (games involving conflicting objectives for each player). We postulate that our recent achievements in defining rationalizable strategies in such games may lead to some new developments in understanding natural systems.
  3. Computational Neuroevolution – We have developed several unique approaches to artificially evolve neural-networks. For example, we suggested a unique algorithm for multi-objective topology and weight evolution of recurrent neural networks. While developed for robotics, we suggest that it may be used for understanding natural systems. Note: The postulations in item 2 and 3 are in accordance with our theory of multi- competence cybernetics. Initial presentation of this theory can be found in: Moshaiov, A. “Multi-competence Cybernetics: The Study of Multi-objective Artificial Systems and Multi- fitness Natural Systems.” In Multiobjective Problem Solving from Nature. Springer Berlin Heidelberg, pp. 285-304, 2008.

Oron Uri

Research topic: Effects of low level laser therapy on stem cells in the bone marrow for the benefit of ischemic organs.

Research methods: In vivo models of ischemia, Histology (light and EM), flow Cytometry.

Main projects in the lab include:

  1. Effect of low level laser therapy (LLLT) application to the bone marrow on the ischemic heart and kidney in experimental animals and humans .
  2. Effect of LLLT to the bone marrow on the cognitive function of Alzheimer’s diseased mice in progressive stages.

Gurevich Tanya

Research topic:  

  1. Experimental neurology and clinical neuroscience
  2. Neurodegenerative diseases
  3. Autonomic nervous system disorders
  4. Hypo and hyperkinetic movement disorders

 Research methods: Clinical research

  1. Experimental clinical therapeutic studies, prospective and retrospective studies in patients with Parkinson’s disease, Parkinson plus syndrome and hyperkinetic movement disorders
  2. Observational studies in patients with hypo- and hyperkinetic movement disorders and patients with autonomic disturbances
  3. Genetic research

 

Projects in the lab include:

  1. Natural history, clinical and autonomic profile of the Multiple system atrophy
  2. Genetic profile of patients with multiple system atrophy
  3. Natural history, clinical profile of the patients with Huntington’s disease of different original
  4. Biomarker Assay Study for the diagnosis of Parkinson’s Disease
  5. Genetic profile of patients with Huntington’s disease of different origin
  6. Epidemiology of Parkinson’s disease
  7. Epidemiology of orthostatic hypotension and clinical profile of patients with different types of orthostatic intolerance
  8. Clinical profile of patients with Parkinson’s disease with different genetic status.
  9. Quality of life of patients with different movement disorders
  10. Respiratory rehabilitation in the movement disorders clinic
  11. Development and refinement of the methods of the interdisciplinary approach to the treatment of movement disorders
  12. Implementation, elaboration and refinement of the methods of interventional neurology and advanced treatments for Parkinson’s disease