Maidan Inbal

Research topic:

  • Explore the neural mechanisms that underlying gait in everyday life environments
  • Identify the compensatory brain mechanisms that are utilized in different neurodegenerative diseases during complex motor-cognitive tasks

Research methods:

  • Cross sectional and longitudinal assessments in clinical setting
  • Neuroimaging such as functional Near-Infra-Red Spectroscopy (fNIRS)
  • Electrophysiology such as Electroencephalography (EEG)

Projects in the lab include:

  • Using EEG to monitor brain activation during walking while performing visual and auditory oddball tasks and identifying changes in the role of cognition during gait in healthy elderly and patients with neurodegenerative diseases.
  • Examine the ability of the prefrontal cortex to compensate for reduced automaticity of motor control with Parkinson's disease progression, and the effects of dopaminergic therapy on this compensation mechanism.

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Exploring changes in EEG during motor and cognitive tasks in patients with Parkinson's disease and Lewy Body Dementia – in collaboration with Prof. Nir Giladi and Prof. Anat Mirelman.
  • Identifying alterations in the compensatory role of the prefrontal cortex with increasing motor-cognitive load – in collaboration with Prof. Anat Mirelman.
  • Assessing the role of prefrontal cortex during complex walking situations that include obstacle negotiation – in collaboration with Prof. Jeffrey Hausdorff. 

Yechiel Levkovitz

Research topic:

  • Affective disorders
  • Schizophrenia
  • Neuromarkers for Affective and Cognitive Improvement

Research methods:

  • Non-invasive brain stimulation
  • Electrophysiology
  • Brain-computer interface
  • Virtual Reality

Projects in the lab include:

  • Exploring Neuromarkers of treatment outcome using neuromodulation in
    patients with Major Depressive Disorder (TMS, EEG, fMRI)
  • Characterizing and monitoring mental disorders using electrophysiological
    tools (Event-related potentials and EEG networks)
  • Evaluation of psychiatric conditions measuring cortical plasticity using TMS
    Evoked potential (simultaneous TMS-EEG)

Achiron Anat

Research topics:

  • Gene expression studies in multiple sclerosis
  • Assessment of brain MRI disease burden using innovative computerized methods
  • Cognitive aspects in autoimmune diseases
  • Epidemiology of multiple sclerosis using big data analyses

Research  methods:

  • Gene expression, Elisa, PCR
  • T cell subpopulation, FACS
  • Statistical analyses of big data
  • Analysis of cortical thickness and brain volume

Projects in the lab include:

  • Classifier for biomarkers to diagnose white matter diseases
  • Assessment of molecular markers in acute multiple sclerosis relapse
  • Prediction of multiple sclerosis disease outcome using gene expression
  • Childhood multiple sclerosis

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof Yaniv Assaf – MRI research in multiple sclerosis using innovative techniques to measure axon diameter

Kalron Alon

Research topic: Motor and cognitive performance in various neurological and orthopedic populations. Primary motor activities of research include gait, balance and physical activity.

Research methods:

  • Laboratory gait analysis via motion sensors, electronic walkway and a computerized treadmill.
  • Posturography analysis.
  • Energy expenditure measurements via a portable metabolic device using breath-by-breath technology (COSMED K5, COSMED Srl, Roma, Italy).
  • Computerized cognitive tests
  • Cortical thickness and subcortical volume based on the Freesurfer MRI analysis suite.

Projects in the lab include:

  1. The acute effects of moderate and vigorous aerobic exercise on cytokine inflammatory markers in women with multiple sclerosis.
  2. Gait and balance in people with Benign Paroxysmal Positional Vertigo (BPPV).
  3. Energy cost and kinematics of uphill and downhill walking in people with multiple sclerosis.
  4. The effect of a combined aerobic and strength exercise program in amyotrophic lateral sclerosis patients.
  5. Performance on the instrumented Timed Up and Go test in people with multiple sclerosis.

 

 

Leitner Yael

Research topic:

Neurodevelopmental outcome of at-risk newborns/children

ADHA

Koton Silvia

Research topic: 

Epidemiology of cardiovascular diseases focusing on differences in stroke morbidity and mortality by population groups, age and aging with special interest in age-related changes in cognitive functioning, long-term effects of cardiovascular risk factors on cognitive functioning, primary and secondary prevention of stroke, health promotion in the elderly and in patients with cardiovascular diseases.

Research methods: Epidemiological methods

Main projects include:

  1. Study of trends in stroke morbidity and mortality
  2. Primary and secondary prevention of stroke including study of novel risk factors for stroke
  3. Study of long-term effects of cardiovascular risk factors

Tamara Shiner

Research topic: Lewy body dementia (DLB) and relationship to mutations in the GBA (glucocerebrosidase) gene, Identification of early markers of neurodegeneration among first degree relatives of patients with Lewy body dementia.

Main projects in the lab include:

  1. Clinical, genetic and neuropsychological assesment of patients with Lewy body dementia and their first degree relatives.
  2. Functional and structural imaging of patients and first degree relatives of patients with Lewy body dementia.

Tanne David

Research topic:

  • Cerebrovascular disease and stroke
  • Vascular cognitive impairment
  • Cerebral atherosclerosis

Research  methods:

  • Epidemiological research
  • Ultrasound-doppler lab
  • Neuroimaging

Projects in the lab include:

  • Trends in stroke morbidity and mortality
  • Vascular function contribution to impaired cognition and stroke
  • Novel risk factors to vascular cognitive impairment, stroke and frailty

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Michal Beeri
  • Prof Sylvia Koton

Mirelman Anat

Research topic:

  • Identification of Early Markers of Neurodegeneration.
  • Understanding the interplay between gait and Cognition.
  • Exploring motor-cognitive reserve in health and disease.

Research  methods:

  • Research in the LEMON lab is performed in a clinical setting. Projects include both cross sectional and longitudinal assessments of patients and population at risk.

Projects in the lab include:

  • Genetics in Parkinson’s disease, identifying disease phenotypes, disease trajectories and progression and early markers of disease in populations in risk.
  • Assessing motor-cognitive reserve. Understanding the relation to neurodegeneration and factors of neuroprotection.
  • Exploring motor and cognitive interaction in neurodegenerative disorders using fNIRS and EEG. Understating neural function during functional performance.
  • Identifying sleep abnormalities using a new combined EEG+EMG system for home based assessment. Collaboration with Prof. Yael Hanin from the Nanotechnology department at TAU.
  • Assessing neural activation during auditory and visual tests using EEG in Parkinson’s disease and Lewy Body Dementia (DLB)

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Assessing common pathways in neurodegenerative disease – in collaboration with Prof. Nir Giladi
  • Motor cognitive interactions in ageing and neurodegeneration – in collaboration with Prof. Jeffrey Hausdorff.
  • Exploring neural activation using fNIRS and EEG in Parkinson’s disease and Lewy Body Dementia- in collaboration with Dr. Tamara Shiner

Tavor Ido

Research topic:

Exploring the relations between brain structure, function and behavior by predicting variability in brain activity and human behavior from brain anatomy and connectivity measurements

Research methods: 

  • Magnetic Resonance Imaging (MRI): functional MRI and diffusion MRI
  • Computational modeling
  • Behavioral experiments

Main projects in the lab include:

  • Predicting task-evoked brain activity from scans acquired at rest
  • Developing behavioral tasks that induce functional and structural brain modifications
  • Investigating the underline mechanisms of functional neuroplasticity as measured with fMRI
  • Characterizing inter-subject variability in brain structure
  • Statistical modeling of MRI data