Maidan Inbal

Research topic:

  • Explore the neural mechanisms that underlying gait in everyday life environments
  • Identify the compensatory brain mechanisms that are utilized in different neurodegenerative diseases during complex motor-cognitive tasks

Research methods:

  • Cross sectional and longitudinal assessments in clinical setting
  • Neuroimaging such as functional Near-Infra-Red Spectroscopy (fNIRS)
  • Electrophysiology such as Electroencephalography (EEG)

Projects in the lab include:

  • Using EEG to monitor brain activation during walking while performing visual and auditory oddball tasks and identifying changes in the role of cognition during gait in healthy elderly and patients with neurodegenerative diseases.
  • Examine the ability of the prefrontal cortex to compensate for reduced automaticity of motor control with Parkinson's disease progression, and the effects of dopaminergic therapy on this compensation mechanism.

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Exploring changes in EEG during motor and cognitive tasks in patients with Parkinson's disease and Lewy Body Dementia – in collaboration with Prof. Nir Giladi and Prof. Anat Mirelman.
  • Identifying alterations in the compensatory role of the prefrontal cortex with increasing motor-cognitive load – in collaboration with Prof. Anat Mirelman.
  • Assessing the role of prefrontal cortex during complex walking situations that include obstacle negotiation – in collaboration with Prof. Jeffrey Hausdorff. 

Artzi Moran

Research topic:

  • Machine Learning in cancer research

Research methods:

  • MRI data
  • Medical image processing, focusing on clinical studies

Yechiel Levkovitz

Research topic:

  • Affective disorders
  • Schizophrenia
  • Neuromarkers for Affective and Cognitive Improvement

Research methods:

  • Non-invasive brain stimulation
  • Electrophysiology
  • Brain-computer interface
  • Virtual Reality

Projects in the lab include:

  • Exploring Neuromarkers of treatment outcome using neuromodulation in
    patients with Major Depressive Disorder (TMS, EEG, fMRI)
  • Characterizing and monitoring mental disorders using electrophysiological
    tools (Event-related potentials and EEG networks)
  • Evaluation of psychiatric conditions measuring cortical plasticity using TMS
    Evoked potential (simultaneous TMS-EEG)

Avraham Ashkenazi

Research topic:  Understanding the cell biology of misfolded proteins that cause neurological disorders

Our research utilizes state-of-the-art technologies to elucidate cellular mechanisms of neurological disorders. Some of these disorders progress late in life, such as Huntington's disease and Parkinson's disease. A common characteristic in these disorders is the accumulation of proteins that are not folded properly and can form aggregates in cells.Research in the lab is currently focused on the ubiquitin and autophagy pathways, the main routes by which aggregate-prone proteins are degraded. Also, these pathways are important for cells to cope with various stress conditions. We aim to elucidate novel regulatory pathways of protein homeostasis in cells to better understand the basis of these devastating diseases and to identify future therapeutic targets.

Research  methods:

  • Model cell lines, neuronal cultures and various tissues from mice and patients.
  • Manipulation of gene expression: knocked down and knock out using transient and lentiviral methods.
  • Advanced imaging.
  • Proteomics and post-translational modification analysis.
  • State-of-the-art biochemistry.
  • Protein and RNA biology.

Dror Dotan

Research topic:

  • The cognitive mechanisms of number processing
  • Math-related learning disabilities
  • Improving math teaching using insights from number-cognition research
  • The relation between the cognitive mechanisms of number processing and language processing
  • What are the cognitive abilities that make good programmers?

Research methods:

  • Neuropsychology – experiments with individuals with impairments in language processing or number processing.
  • Classical cognitive psychology behavioral experiments.
  • Analysis of finger trajectories in decision tasks.
  • Analysis of pen trajectories in writing tasks.
  • Intervention (teaching) programs – in the lab.
  • Web-based intervention programs

Projects in the lab include:

  • How do we read and write numbers, and why can’t some of us do it? Understanding the cognitive mechanisms of number reading and writing, and the learning disabilities that affect these processes.
  • The syntax of numbers The mental representation of multi-digit as hierarchies, and its relation to the hierarchical representation of sentences.
  • How can we help children learn the multiplication table? Revealing how arithmetic facts are stored in memory, and finding ways to make their memorization easier.
  • How do programmers think of programs? Discover how programmers mentally represent the structure of computer programs.

Dr. Arnon Karni

Research topic:

  • Induction of neurogenesis in the CNS , focusing on multiple sclerosis.
  • Immune mediated neurogenesis and neurprotection.

Research methods:

  • Cellular immunology.
  • Animal models.
  • ELISA, FACS, WB, cell separation, etc.
  • According to the needs of the research project

Achiron Anat

Research topics:

  • Gene expression studies in multiple sclerosis
  • Assessment of brain MRI disease burden using innovative computerized methods
  • Cognitive aspects in autoimmune diseases
  • Epidemiology of multiple sclerosis using big data analyses

Research  methods:

  • Gene expression, Elisa, PCR
  • T cell subpopulation, FACS
  • Statistical analyses of big data
  • Analysis of cortical thickness and brain volume

Projects in the lab include:

  • Classifier for biomarkers to diagnose white matter diseases
  • Assessment of molecular markers in acute multiple sclerosis relapse
  • Prediction of multiple sclerosis disease outcome using gene expression
  • Childhood multiple sclerosis

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof Yaniv Assaf – MRI research in multiple sclerosis using innovative techniques to measure axon diameter

Leitner Yael

Research topic:

Neurodevelopmental outcome of at-risk newborns/children

ADHA

Liat Ben-Sira (Beinart)

Research topic:

  • Fetal M.R.I.
  • Brain malformation-neuro-development follow-up

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof. Dafna Ben-Bashat
  • Prof. Yaniv Assaf

Barak Boaz

Research topic:

  • Neurobiology of genetic neurodevelopmental disorders such as Williams syndrome and autism spectrum disorders.
  • Dissecting neural circuits and brain regions’ roles in anxiety-like and social behavior.
  • Therapeutic approaches to improve behavioral abnormalities in mouse models for psychiatric disorders.

Research  methods:

  • Molecular and cellular biology
  • In vivo optogenetics and pharmacogenetics
  • Behavioral tests
  • Stereotaxic surgical techniques for gene delivery
  • Nucleic acid methods
  • Transgenic and conditional knockout mouse models
  • Histology and microscopy
  • In vitro cell-based assays

Projects in the lab include:

  • In vivo optogenetic manipulation of social behavior abnormalities in mouse models for psychiatric disorders
  • Gene-rescue treatments to restore behavior and physiology in mouse models for psychiatric disorders
  • Defining the postnatal developmental and functional roles of genes in mouse models for psychiatric disorders
  • Pharmacological and pharmacogenetical studies to treat psychiatric disorders
  • Neuron-glia interactions and their role in the pathophysiology of psychiatric disorders
  • Production and characterization of novel mouse models for genetic neuropsychiatric disorders