Dr. Arnon Karni

Research topic:

  • Induction of neurogenesis in the CNS , focusing on multiple sclerosis.
  • Immune mediated neurogenesis and neurprotection.

Research methods:

  • Cellular immunology.
  • Animal models.
  • ELISA, FACS, WB, cell separation, etc.
  • According to the needs of the research project

Achiron Anat

Research topics:

  • Gene expression studies in multiple sclerosis
  • Assessment of brain MRI disease burden using innovative computerized methods
  • Cognitive aspects in autoimmune diseases
  • Epidemiology of multiple sclerosis using big data analyses

Research  methods:

  • Gene expression, Elisa, PCR
  • T cell subpopulation, FACS
  • Statistical analyses of big data
  • Analysis of cortical thickness and brain volume

Projects in the lab include:

  • Classifier for biomarkers to diagnose white matter diseases
  • Assessment of molecular markers in acute multiple sclerosis relapse
  • Prediction of multiple sclerosis disease outcome using gene expression
  • Childhood multiple sclerosis

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof Yaniv Assaf – MRI research in multiple sclerosis using innovative techniques to measure axon diameter

Leitner Yael

Research topic:

Neurodevelopmental outcome of at-risk newborns/children

ADHA

Liat Ben-Sira (Beinart)

Research topic:

  • Fetal M.R.I.
  • Brain malformation-neuro-development follow-up

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof. Dafna Ben-Bashat
  • Prof. Yaniv Assaf

Barak Boaz

Research topic:

  • Neurobiology of genetic neurodevelopmental disorders such as Williams syndrome and autism spectrum disorders.
  • Dissecting neural circuits and brain regions’ roles in anxiety-like and social behavior.
  • Therapeutic approaches to improve behavioral abnormalities in mouse models for psychiatric disorders.

Research  methods:

  • Molecular and cellular biology
  • In vivo optogenetics and pharmacogenetics
  • Behavioral tests
  • Stereotaxic surgical techniques for gene delivery
  • Nucleic acid methods
  • Transgenic and conditional knockout mouse models
  • Histology and microscopy
  • In vitro cell-based assays

Projects in the lab include:

  • In vivo optogenetic manipulation of social behavior abnormalities in mouse models for psychiatric disorders
  • Gene-rescue treatments to restore behavior and physiology in mouse models for psychiatric disorders
  • Defining the postnatal developmental and functional roles of genes in mouse models for psychiatric disorders
  • Pharmacological and pharmacogenetical studies to treat psychiatric disorders
  • Neuron-glia interactions and their role in the pathophysiology of psychiatric disorders
  • Production and characterization of novel mouse models for genetic neuropsychiatric disorders

Weiser Mark

Research topic:

  • Schizophrenia
  • Clinical trials

Research methods:

  • Epidemiology using data-bases
  • Clinical trials

Projects in the lab include:

  • PSYSCAN project. European Union. Israel Coordinator. 12,000,000€.
  • PURPOSE project: Placebo-controlled trial in subjects at ultra-high risk for psychosis with Omega-3 fatty acids in Europe. European Union. Israel. Coordinator. $2,500,000.
  • Methotrexate for schizophrenia, PI, Stanley Medical Research Institute. $1,000,000.

Schreiber Shaul

Research topic: 

  1. Post Traumatic Stress Disorder (PTSD)
  2. Minimal traumatic brain injury (mTBI)
  3. Opiate addiction & methadone maintenance treatment (MMT)

Research methods: Clinical studies

Koton Silvia

Research topic: 

Epidemiology of cardiovascular diseases focusing on differences in stroke morbidity and mortality by population groups, age and aging with special interest in age-related changes in cognitive functioning, long-term effects of cardiovascular risk factors on cognitive functioning, primary and secondary prevention of stroke, health promotion in the elderly and in patients with cardiovascular diseases.

Research methods: Epidemiological methods

Main projects include:

  1. Study of trends in stroke morbidity and mortality
  2. Primary and secondary prevention of stroke including study of novel risk factors for stroke
  3. Study of long-term effects of cardiovascular risk factors

Rotenstreich Ygal

Research topic:

  • The eye as a window to the brain – using retinal structure and function measurements as novel early and objective biomarkers for brain neurodegeneration diseases (e.g. Alzheimer’s disease and multiple sclerosis), brain injuries and brain tumors.
  • Development of novel treatments for neuroretinal degeneration
  • Development of innovative diagnostic tools for macular, retinal degeneration and optic nerve diseases

Research methods:

  • Clinical trials – ophthalmic, imaging and pupillometry analyses
  • Animal research including transgenic rodent models for neuroretinal diseases
  • Molecular biology, tissue cultures and advanced in vivo imaging

Projects in the lab include:

  • Retinal structure and function measurements as novel objective biomarkers for Alzheimer’s disease
  • Chromatic multifocal pupillometry for objective assessment of optic neuritis and multiple sclerosis
  • Chromatic multifocal pupillometry for objective assessment and early detection of changes in intracranial pressure and acute brain injury
  • Development of stem cell therapies for neuroretinal degeneration – pre-clinical studies and clinical trials
  • The role of microglia activation in neuroretinal degeneration and development of microglia-blocking treatments for incurable retina degeneration
  • Chromatic multifocal pupillometry – an innovative diagnostic tool for objective assessment of macular, retinal degeneration and optic nerve diseases

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Retinal Structure and function as novel objective biomarkers for Alzheimer’s disease – in collaboration with Prof. Michal Beeri and Dr. Ramit Ravona-Springer

Rechavi Gidi

Research topic: Epitranscriptomics (RNA epigenetics), Transposable genetic elements in the brain, Genes mutated in neurodevelopmental disorders.

Research methods: Next generation sequencing, Bioinformatics

Main projects in the lab include:

  1. RNA editing in the brain.
  2. RNA methylation in neurodegenerative diseases.