Maidan Inbal

Research topic:

  • Explore the neural mechanisms that underlying gait in everyday life environments
  • Identify the compensatory brain mechanisms that are utilized in different neurodegenerative diseases during complex motor-cognitive tasks

Research methods:

  • Cross sectional and longitudinal assessments in clinical setting
  • Neuroimaging such as functional Near-Infra-Red Spectroscopy (fNIRS)
  • Electrophysiology such as Electroencephalography (EEG)

Projects in the lab include:

  • Using EEG to monitor brain activation during walking while performing visual and auditory oddball tasks and identifying changes in the role of cognition during gait in healthy elderly and patients with neurodegenerative diseases.
  • Examine the ability of the prefrontal cortex to compensate for reduced automaticity of motor control with Parkinson's disease progression, and the effects of dopaminergic therapy on this compensation mechanism.

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Exploring changes in EEG during motor and cognitive tasks in patients with Parkinson's disease and Lewy Body Dementia – in collaboration with Prof. Nir Giladi and Prof. Anat Mirelman.
  • Identifying alterations in the compensatory role of the prefrontal cortex with increasing motor-cognitive load – in collaboration with Prof. Anat Mirelman.
  • Assessing the role of prefrontal cortex during complex walking situations that include obstacle negotiation – in collaboration with Prof. Jeffrey Hausdorff. 

Kalron Alon

Research topic: Motor and cognitive performance in various neurological and orthopedic populations. Primary motor activities of research include gait, balance and physical activity.

Research methods:

  • Laboratory gait analysis via motion sensors, electronic walkway and a computerized treadmill.
  • Posturography analysis.
  • Energy expenditure measurements via a portable metabolic device using breath-by-breath technology (COSMED K5, COSMED Srl, Roma, Italy).
  • Computerized cognitive tests
  • Cortical thickness and subcortical volume based on the Freesurfer MRI analysis suite.

Projects in the lab include:

  1. The acute effects of moderate and vigorous aerobic exercise on cytokine inflammatory markers in women with multiple sclerosis.
  2. Gait and balance in people with Benign Paroxysmal Positional Vertigo (BPPV).
  3. Energy cost and kinematics of uphill and downhill walking in people with multiple sclerosis.
  4. The effect of a combined aerobic and strength exercise program in amyotrophic lateral sclerosis patients.
  5. Performance on the instrumented Timed Up and Go test in people with multiple sclerosis.

 

 

Shein-Idelson Mark

Research topic:
• Organization of population dynamics and coding across brain states.
• Evolution of neuronal computation.

Research methods:
• In-vivo and in-vitro large-scale, high-density extracellular electrophysiology.
• Signal processing and data analysis
• Computational modelling
• Intra-cellular electrophysiology

Projects in the lab include:
• Visual processing in the ancestral three layered cortex of turtles.
• Mechanistic sources of neuronal variability and their impact on coding.
• Organization of neuronal activity during interaction between oscillating sub-populations.
• Continuous monitoring and processing of 3D posture information in reptiles.
• Evolution of cortical computation – investigation of the amphibian dorsal pallium.

Barak Boaz

Research topic:

  • Neurobiology of genetic neurodevelopmental disorders such as Williams syndrome and autism spectrum disorders.
  • Dissecting neural circuits and brain regions’ roles in anxiety-like and social behavior.
  • Therapeutic approaches to improve behavioral abnormalities in mouse models for psychiatric disorders.

Research  methods:

  • Molecular and cellular biology
  • In vivo optogenetics and pharmacogenetics
  • Behavioral tests
  • Stereotaxic surgical techniques for gene delivery
  • Nucleic acid methods
  • Transgenic and conditional knockout mouse models
  • Histology and microscopy
  • In vitro cell-based assays

Projects in the lab include:

  • In vivo optogenetic manipulation of social behavior abnormalities in mouse models for psychiatric disorders
  • Gene-rescue treatments to restore behavior and physiology in mouse models for psychiatric disorders
  • Defining the postnatal developmental and functional roles of genes in mouse models for psychiatric disorders
  • Pharmacological and pharmacogenetical studies to treat psychiatric disorders
  • Neuron-glia interactions and their role in the pathophysiology of psychiatric disorders
  • Production and characterization of novel mouse models for genetic neuropsychiatric disorders

Tamara Shiner

Research topic: Lewy body dementia (DLB) and relationship to mutations in the GBA (glucocerebrosidase) gene, Identification of early markers of neurodegeneration among first degree relatives of patients with Lewy body dementia.

Main projects in the lab include:

  1. Clinical, genetic and neuropsychological assesment of patients with Lewy body dementia and their first degree relatives.
  2. Functional and structural imaging of patients and first degree relatives of patients with Lewy body dementia.

Mirelman Anat

Research topic:

  • Identification of Early Markers of Neurodegeneration.
  • Understanding the interplay between gait and Cognition.
  • Exploring motor-cognitive reserve in health and disease.

Research  methods:

  • Research in the LEMON lab is performed in a clinical setting. Projects include both cross sectional and longitudinal assessments of patients and population at risk.

Projects in the lab include:

  • Genetics in Parkinson’s disease, identifying disease phenotypes, disease trajectories and progression and early markers of disease in populations in risk.
  • Assessing motor-cognitive reserve. Understanding the relation to neurodegeneration and factors of neuroprotection.
  • Exploring motor and cognitive interaction in neurodegenerative disorders using fNIRS and EEG. Understating neural function during functional performance.
  • Identifying sleep abnormalities using a new combined EEG+EMG system for home based assessment. Collaboration with Prof. Yael Hanin from the Nanotechnology department at TAU.
  • Assessing neural activation during auditory and visual tests using EEG in Parkinson’s disease and Lewy Body Dementia (DLB)

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Assessing common pathways in neurodegenerative disease – in collaboration with Prof. Nir Giladi
  • Motor cognitive interactions in ageing and neurodegeneration – in collaboration with Prof. Jeffrey Hausdorff.
  • Exploring neural activation using fNIRS and EEG in Parkinson’s disease and Lewy Body Dementia- in collaboration with Dr. Tamara Shiner

Tavor Ido

Research topic:

Exploring the relations between brain structure, function and behavior by predicting variability in brain activity and human behavior from brain anatomy and connectivity measurements

Research methods: 

  • Magnetic Resonance Imaging (MRI): functional MRI and diffusion MRI
  • Computational modeling
  • Behavioral experiments

Main projects in the lab include:

  • Predicting task-evoked brain activity from scans acquired at rest
  • Developing behavioral tasks that induce functional and structural brain modifications
  • Investigating the underline mechanisms of functional neuroplasticity as measured with fMRI
  • Characterizing inter-subject variability in brain structure
  • Statistical modeling of MRI data

Schreiber Shaul

Research topic: 

  1. Post Traumatic Stress Disorder (PTSD)
  2. Minimal traumatic brain injury (mTBI)
  3. Opiate addiction & methadone maintenance treatment (MMT)

Research methods: Clinical studies

Rotenstreich Ygal

Research topic:

  • The eye as a window to the brain – using retinal structure and function measurements as novel early and objective biomarkers for brain neurodegeneration diseases (e.g. Alzheimer’s disease and multiple sclerosis), brain injuries and brain tumors.
  • Development of novel treatments for neuroretinal degeneration
  • Development of innovative diagnostic tools for macular, retinal degeneration and optic nerve diseases

Research methods:

  • Clinical trials – ophthalmic, imaging and pupillometry analyses
  • Animal research including transgenic rodent models for neuroretinal diseases
  • Molecular biology, tissue cultures and advanced in vivo imaging

Projects in the lab include:

  • Retinal structure and function measurements as novel objective biomarkers for Alzheimer’s disease
  • Chromatic multifocal pupillometry for objective assessment of optic neuritis and multiple sclerosis
  • Chromatic multifocal pupillometry for objective assessment and early detection of changes in intracranial pressure and acute brain injury
  • Development of stem cell therapies for neuroretinal degeneration – pre-clinical studies and clinical trials
  • The role of microglia activation in neuroretinal degeneration and development of microglia-blocking treatments for incurable retina degeneration
  • Chromatic multifocal pupillometry – an innovative diagnostic tool for objective assessment of macular, retinal degeneration and optic nerve diseases

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Retinal Structure and function as novel objective biomarkers for Alzheimer’s disease – in collaboration with Prof. Michal Beeri and Dr. Ramit Ravona-Springer

Peles Einat

Research topic: 

  1. Methadone maintenance treatment; opioid addiction, addiction; mental disorders
  2. Sleep, Pain, Cognition, Stress.

Joint projects with other Faculty members in the Sagol School of Neuroscience:

Ruth Defrin