Sagol faculty

Segal

Prof. Daniel Segal

Dept. of Molecular Microbiology & Biotechnology, Life Sciences Faculty


Tel: 03-6409835

Email

Research topic: Develop and use Drosophila models of neurodegenerative diseases for drug discovery and their validation in rodents (in collaboration with the labs of Ehud Gazit, Dan Frenkel)

Research methods: In vitro and bacterial assays of protein folding and aggregation, cytotoxcisity assays in cell culture, genetics and molecular biology of transgenics, immunohistochemistry, behavioral and cognitive assays.

Main projects in the lab include:

  1. Develop and screen in vivo novel small molecules as amyloid-beta and tau inhibitors in Alzheimer’s disease
  2. Develop and screen natural compounds as amyloid-beta and tau inhibitors in Alzheimer’s disease
  3. Develop and screen in vivo novel small molecules as alpha-synuclein inhibitors in Parkinson’s disease
  4. Develop and screen in vivo novel small molecules as TDP-43 inhibitors in ALS
  5. Examine the role of protein glycosylation in the aging and neurodegenerative brain