Research topic: Elucidating the decoding mechanisms of ubiquitin signals and their significance in neurodegenerative diseases
Research methods: Biophysical measurements including SPR, AUC, MST and SEC, X-ray crystallography, Bioinformatics, Biochemistry and bacterial genetics
Projects in the lab include:
- Molecular mechanisms that regulate membrane protein trafficking and Parkinson’s disease
- Mechanisms for regulation of sodium / potassium channels and dopamine transporter.
- The molecular basis of the involvement of the ubiquitin E3-ligases Ube3A and Ube3B in autism
- The involvement of ubiquitin-receptors in amyloid formation.