Research topic: Elucidating the role of axonal transport and motor proteins in neurodegeneration and neuromuscular junction maintenance.
Neuronal survival and proper function depends on cell-cell communication mediated by ligand-receptor mechanisms. During neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), there is considerable neuromuscular junction (NMJ) disruption and neuronal cell death. It is non-autonomous processes involve interactions between the neurons to its diverse extracellular microenvironments. The molecular basis for this neuronal dysfunction and death is still poorly understood. The long-term research goal of the lab is to understand the molecular communications mechanisms between the neurons to its environment and to understand the role that retrograde signaling plays in:
- Neuronal survival
- Synapse stability
Research methods: Molecular and cellular neurobiology, Live cell imaging, Super resolution microscopy, primary co-culture, single molecule motility assays, proteomics, genomics.
Main projects in the lab include:
- Retrograde signaling between muscle and the motor neurons
- Neurotrophic factors receptors dynamics along the cell surface
- Axonal RNA transport in health and disease