Research topic: We strive to better understand the mechanisms of autoimmunity and inflammation that underlie neurologic diseases and to translate these laboratory discoveries into new therapies.
Research methods: We take a transdisciplinary approach in our research endeavors using immunologic, genomic, proteomic and metabolomic approaches to study neuroinflammation in pre-clinical (murine) and clinical models. Our research combines state of the art technologies such as single-cell genome-wide sequencing, genomic editing, in-vivo imaging, targeted and un-targeted mass-spectrometry, in-situ molecular imaging and real-time metabolic analysis.
Main projects in the lab include:
- Elucidating the immune function of the different glial cells in autoimmune diseases and neurologic disorders.
- Investigating the immunometabolic response in the brain.
- Studying the crosstalk between the innate and adaptive immune systems in the central nervous system.
- Exploring the immunological aspects of the astrocyte-neuron relationship.
- Developing novel strategies for manipulating glial activation and autoimmune responses.