Sagol faculty


Prof. Gerardo Lederkremer

Dept. of Cell Research and Immunology, Faculty of Life Sciences

Tel: 03-6409239



Research topic: Development and role of endoplasmic reticulum stress in the pathogenesis of neurodegenerative diseases.

Research methods: Molecular biology, Cell biology, Biochemistry, Protein chemistry, Glycan structural analysis, Immunohistochemistry, Cryosection analysis, Immunofluorescence, Confocal microscopy, STED microscopy, Live cell imaging.

Projects in the lab include:

  1. Study of cellular compartmentalization in the response to endoplasmic reticulum (ER) stress in Huntington’s and other neurodegenerative diseases.
  2. Search for drugs that interfere with ER stress induced apoptosis in the brain striatum in Huntington’s disease.
  3. Mechanisms of ER quality control and ER-associated degradation (ERAD) in normal and disease model neurons.