Research topic: Cancer biophysics: dynamics, organization, endocytosis and recycling of receptors and signaling proteins that regulate cell proliferation and cancer.
Research methods: Quantitative fluorescence microscopy imaging, quantitative FRAP (Fluorescence Recovery After Photobleaching) and diffusion analysis in live cells, FRAP beam-size analysis to determine membrane binding/unbinding of non-integral membrane proteins, single molecule imaging (diffusion and oligomerization studies), membrane protein interactions in live cells by patch/FRAP and by fluorescence correlation spectroscopy, quantitative endocytosis rate and recycling studies.
Projects in the lab include:
- Role of transforming growth factor-b (TGF-b) receptors oligomerization and endocytosis in the negating effects of TGF-b in cancer.
- Trafficking and signaling of bone morphogenetic protein (BMP) receptors: molecular motifs and regulatory interactions.
- Biophysical studies on the interactions of lipid-anchored oncoproteins (Ras and Src) with cell membranes and focal adhesions, and their roles in signaling and transformation.