Sagol faculty

Haitin-Yoni-sagol-profile

Dr. Yoni Haitin

Dept. of Physiology and Pharmacology, Sackler School of Medicine


Tel: 054-9277969

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Research topic: The Molecular Basis of the Regulation of Microglial cells activity by Ion Channels

Research methods: Fluorescence-detection Size-Exclusion Chromatography (FSEC), membrane protein purification, proteoliposome reconstitution, unnatural amino acids (UAA) incorporation, transition-ion metal Fluorescence Resonance Energy Transfer (FRET), electrophysiology, patch clamp fluorometry, x-ray crystallography, deep mutational scanning, Single molecule Total Internal Reflection Microscopy (TIRF) imaging.

Projects in the lab include:

  1. Identification of the molecular determinants governing the activation of Ca2+-activated chloride channels.
  2. Elucidate the molecular rearrangements and architecture of membrane-embedded anion conductive Chloride Intracellular Channel (CLIC).
  3. Explore the functional expression and physiological importance of anion channels in resting and activated microglia