Research topic: Multi-level approach to the study of brain function, behavior, memory and drug discovery, from molecules to cures. The laboratory has discovered novel families of proteins associated with cross talk among nerve cells and their support cells, including activity-dependent neurotrophic factor (ADNF) and activity-dependent neuroprotetive proteins (ADNPs). Small ADNF and ADNP derivatives are in clinical development. Novel compounds are being discovered at the level of association with the neuronal skeleton and transport system. Major disease oriented research is focused on autism, Alzheimer’s disease and schizophrenia: biomarkers and novel drug candidates. Prof. Gozes served as Founding Scientist and Director at Allon Therapeutics. Prof. Gozes serves as the Editor-in-Chief of the Journal of Molecular Neuroscience (http://www.editorialmanager.com/jomn/).
Research methods: Molecular biology, RNA silencing, Cell Biology, Confocal Microscopy, Immunofluoresence, Live cell imaging, Immunohistochemistry, Protein biochemistry, Peptide chemistry, Animal models, Behavioral tests, Biomarkers.
Main projects in the lab include:
- Mechanism of neurodegeneration and neuroprotection in Alzheimer’s disease and related neurodegeneration: from gene to cell to behavior
- Schizophrenia and autism in relation to the nerve cell architecture and transport mechanism
- Novel biomarkers, drug discovery and development