Research topics: Amyloid formation and degenerative disease using In- vitro and In- vivo models; Molecular structure and self-assembly at the nano-scale; Nano-scale peptide assemblies; the Role of Protein Folding and Stability in the HIV capsid model.
Research methods: Molecular biology; Peptide array; Protein expression and purification; ThT fluorescence assay; Western blot analysis of protein assembly; DLS analysis; NMR analysis; CD characterization and analysis; Cell culture; Transmission electron microscopy; Fly and mice disease models; Immunohistochemistry.
Projects in the lab:
- Utilization of a variety of biochemical, biophysical and molecular biology methodologies to study the mechanism and significance of protein unfolding and misfolding
- Identification of the self-assembly process of endogenous amyloidogenic proteins in neurodegenerative diseases
- Targeting the central recognition interface of amyloids by employing aromatic elements for the inhibition of protein self-assembly into ordered structures, both In-vivo and In-vitro
- Characterization and inhibition of HIV capsid self-assembly