Research topic: We investigate the mechanisms of endocrine and genetic regulation of bone remodeling. We have several projects aimed at elucidating the control of bone remodeling by the brain.
Research methods: Micro-computed tomography, fluorescent and immuno-histomorphometry, molecular biology, TBI, bioinformatics, biomechanics.
Projects in the lab include:
- Our GWAS identified genes regulating Oxytocin production as causal determinant of bone microarchitecture in the appendicular skeleton. Because Oxytocin is normally produced in the hypothalamus and stored in the posterior pituitary gland, our results emphasize the physiological relevance of the Bran-to-Bone communication.
- We also study the effect of traumatic brain injury (TBI) on bone formation in the calvarial bone and its link to the endocannabinoid system.