Research topic: Understanding the mechanisms of cancer cell reprogramming and the contributions of the tumor microenvironment.
Research methods: We use an integrative approach to study brain tumor (glioma)-specific neurobiology and oncobiology. Our lab combines cell biology, molecular biology, biochemistry, immunology, cancer research, as well as advanced genome-wide techniques and microscopy. To recapitulate human brain tumors in a mouse model, we use inducible-lentiviral vectors to introduce oncogenes/tumor suppressor genes in a cell-type and tissue specific manner.
Projects in the lab include:
- Examining the parallel changes in oncogenesis and the induction of pluripotency.
- Elucidating the mechanisms involved in cancer cell plasticity.
- Identifying the molecular events involved in gliomagenesis.
- Designing novel therapeutic approaches to glioblastoma, combining adoptive immune gene therapy and nanotechnology.