Our research focuses on understanding mechanisms of gene regulation. We aim at elucidating, using bioinofrmatic methods and analysis of various omic datasets, how gene expression is regulated at the layers of transcription, stability and translation, and at discovering how interruptions in these regulatory mechanisms contribute to the development of human pathological conditions.
Research methods: Bioinformatics; systems biology; omics data obtained by various deep-sequencing techniques
Projects in the lab include:
- Elucidate mechanisms that regulate gene expression at the layers of transcription, transcript stability and protein translation.
- Identify key regulatory modules that dictate cell fate in the CNS.
- Elucidate the effect of genetic risk variants for brain diseases on gene regulation