Research topics: molecular mechanisms of neuronal excitability, signal transduction by neurotransmitters, and their relation to human disease.
Research methods: Electrophysiology, Protein Biochemistry, Fluorescence Resonance Energy Transfer (FRET), Single Molecule Biophysics and Imaging, Molecular biology, Mathematical and Kinetic Modeling and Simulation, Immunocytochemistry
Projects in the lab:
- Molecular mechanisms of function and regulation of G protein activated K+ channels (GIRK) and neuronal Ca2+ channels (Cav2) in health and disease.
- The diverse coupling of G protein-coupled receptors with G proteins and effectors in heterologous expression systems and in nerve cells.
- Molecular mechanisms of bipolar disorder (manic-depression disorder) and schizophrenia: Relation between neuronal function, ion channels, drugs and disorders’ genetics. Collaboration with:Prof. Bernard Attali, Sagol School of Neuroscience
- Na channel mutations and infantile epilepsy (Dravet syndrome): from clinic to lab bench and back. Collaboration with: Dr. Andreea Nissenkorn, Pediatric Neurology Unit, Safra Children’s Hosptial, Sheba Medical Center