Research topic: Molecular regulation of sleep-like behaviour in the genetically tractable C. elegans model. Interactions between neuronal and metabolic signalling pathways.
Research methods: Live imaging, confocal microscopy, genetics, molecular biology, biochemistry
Projects in the lab include: We aim to understand how interactions among genetic conditions, biochemical modifications, dynamic subcellular organelles and physiological processes result in integrated organismal responses (embryonic development, stress response, aging and sleep). We approach our objectives using C. elegans, a microscopic round worm which has been a key multicellular model for biological discovery over the past 40 years.
- Regulation of sleep-like behavior by post-translational protein modifications.
- Regulation of embryonic morphogenesis by SUMO (small ubiquitin-like modifier)
- Regulation of stress response and aging by the E3 ubiquitin ligase RNF-5