Sagol faculty


Prof. Abdussalam Azem

Dept. of Biochemistry and Molecular Biology; George S. Wise Faculty of Life Sciences




Research topic: Understanding the function of mitochondria at the molecular level.

Research methods: The primary research approach that we utilize is reconstitution of a studied system from individual purified proteins.  We then employ a wide range of biochemistry and biophysics methods to study the structural properties of the reconstituted complexes, in vitro. Finally, we use functional assays (protein refolding and import) to establish a mechanistic link between the structure and function.  In parallel, we study the behavior of protein variants in a living system, using bacterial and yeast as model systems of normal and disease causing proteins.

Projects in the lab include:

  1. Molecular function of mitochondrial molecular chaperones on protein folding.
  2. Molecular mechanism of function mitochondrial protein import machinery.
  3. Nuclear encoded protein as a cause of mitochondrial disease.