Research topic: Understanding the function of mitochondria at the molecular level.
Research methods: The primary research approach that we utilize is reconstitution of a studied system from individual purified proteins. We then employ a wide range of biochemistry and biophysics methods to study the structural properties of the reconstituted complexes, in vitro. Finally, we use functional assays (protein refolding and import) to establish a mechanistic link between the structure and function. In parallel, we study the behavior of protein variants in a living system, using bacterial and yeast as model systems of normal and disease causing proteins.
Projects in the lab include:
- Molecular function of mitochondrial molecular chaperones on protein folding.
- Molecular mechanism of function mitochondrial protein import machinery.
- Nuclear encoded protein as a cause of mitochondrial disease.