Sagol faculty

Avraham-Karen-sagol-profile

Prof. Karen Avraham

Dept. of Human Molecular Genetics and Biochemstry, Sackler Faculty of Medicine


Tel: 03-6407030

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Research topic: Characterization of genes in the human deaf population and corresponding mouse models; the regulation by microRNAs in the auditory and vestibular systems and their targets; networks of genes and proteins in the auditory system using transcriptomics and proteomics; the correlation between anxiety and balance defects in mouse models.

Research methods: Deep sequencing/massively parallel sequencing, gene cloning, quantitative RT-PCR, immunofluorescence, yeast two-hybrid assays, cell culture, scanning electron microscopy, mass spectrometry, in situ hybridization, bioinformatics.

Main projects in the lab include:

  1. Discovery and characterization of genes for inherited hearing loss in humans using deep sequencing technology
  2. microRNA regulation in the auditory and vestibular systems and link to deafness
  3. Identification of microRNA targets in the mammalian inner ear
  4. Characterization of mouse models for human forms of deafness
  5. Gene therapy in a loxP-cre connexin 26 mouse model for human deafness
  6. The search for biological networks of hearing: a transcriptomics and proteomics approach