Sagol faculty

Attali-Bernard-sagol-profile

Prof. Bernard Attali

Dept. of Physiology & Pharmacology, Sackler Faculty of Medicine


Tel: 03-6405116

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Research topic: Structure, biophysics and physiology of normal and diseased potassium channels in the brain and heart

Research methods: Electrophysiology (voltage- and current-clamp modes of the patch-clamp technique), simultaneous optical and electrophysiological recording (FRET spectral analysis and voltage-clamp), hippocampal slice recording, TIRF imaging and various biochemical methods (pull-down and SPR)

Main projects in the lab include:

  1. Tuning of voltage-gated potassium channels by Src family tyrosine kinases and tyrosine phosphatases in the hippocampus: impact on excitability
  2. Role of Kv7.2/3 channels in hippocampal neurotransmission in a neurodevelopmental rat model of schizophrenia
  3. Targeting the voltage sensor of Kv7 and TRPV1 channels with gating-modifier molecules to prevent neuronal hyperexcitability
  4. Subunit interactions in Kv7 potassium channels: gating, thermodynamics, cooperativity and implications for diseased long QT mutations
  5. Assembly rules of the cardiac Kv7.1 potassium channel complex and crystal structure of the intracellular domains (in collaboration with Dr. Joel Hirsch)
  6. Mechanisms underlying the pacemaker activity in developing human embryonic stem cell-derived cardiomyocytes