Ronit Satchi-Fainaro

Research topic:

Our research focuses on the brain microenvironment in which a primary or a secondary tumor arises, and the critical influence that recruited non-cancerous stromal cells, such as astrocytes, microglia, neurons, endothelial and immune cells, can have on brain tumor progression, metastasis and response to therapy.

Research  methods:

We employ a range of multi-disciplinary complementary strategies to address our questions including the establishment of new mouse models of human and murine cancers, 3D bioprinting, computational approaches, and analysis of patient samples in collaboration with our clinical colleagues. Our ultimate goal is to apply this knowledge to the clinic by developing targeted therapies that disrupt essential tumor-microenvironment interactions using nanotechnology, polymer chemistry, and smart Turn-ON probes for intravital non-invasive molecular imaging.

Projects in the lab include:

  1. Elucidating the molecular mechanisms involved in glioblastoma – brain          microenvironment interactions.
  2. Uncovering the role of astrocytes-mediated neuroinflammation in the establishment of melanoma brain metastasis.
  3. Unraveling the role of microglia in primary and secondary brain neoplasms.
  4. Identifying the mechanisms by which cells in the brain microenvironment regulate invasion and metastatic colonization of melanoma, breast and lung cancer.
  5. Identifying the mechanisms underlying the contribution of the brain microenvironment to therapeutic resistance.
  6. Rational design of precision theranostic nanomedicines for brain neoplasms.

 

Ben Maoz

Research topic:  

  • Cellular interaction in the Neurovascular Unit.
  • Traumatic Brain injury.

Research  methods:

  • Organs-on-a-chip
  • Omics methods, such as proteomics, metabolomics, etc.
  • Electrophysiology.

Projects in the lab include:

  • Studying how traumatic brain injury effect the neurovascular unit.
  • Development of new tools for the study of brain physiology (e.g. Organs on a chip for the study of the neurovascular unit). 

 

 

Dr. Arnon Karni

Research topic:

  • Induction of neurogenesis in the CNS , focusing on multiple sclerosis.
  • Immune mediated neurogenesis and neurprotection.

Research methods:

  • Cellular immunology.
  • Animal models.
  • ELISA, FACS, WB, cell separation, etc.
  • According to the needs of the research project

Achiron Anat

Research topics:

  • Gene expression studies in multiple sclerosis
  • Assessment of brain MRI disease burden using innovative computerized methods
  • Cognitive aspects in autoimmune diseases
  • Epidemiology of multiple sclerosis using big data analyses

Research  methods:

  • Gene expression, Elisa, PCR
  • T cell subpopulation, FACS
  • Statistical analyses of big data
  • Analysis of cortical thickness and brain volume

Projects in the lab include:

  • Classifier for biomarkers to diagnose white matter diseases
  • Assessment of molecular markers in acute multiple sclerosis relapse
  • Prediction of multiple sclerosis disease outcome using gene expression
  • Childhood multiple sclerosis

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof Yaniv Assaf – MRI research in multiple sclerosis using innovative techniques to measure axon diameter

Kalron Alon

Research topic: Motor and cognitive performance in various neurological and orthopedic populations. Primary motor activities of research include gait, balance and physical activity.

Research methods:

  • Laboratory gait analysis via motion sensors, electronic walkway and a computerized treadmill.
  • Posturography analysis.
  • Energy expenditure measurements via a portable metabolic device using breath-by-breath technology (COSMED K5, COSMED Srl, Roma, Italy).
  • Computerized cognitive tests
  • Cortical thickness and subcortical volume based on the Freesurfer MRI analysis suite.

Projects in the lab include:

  1. The acute effects of moderate and vigorous aerobic exercise on cytokine inflammatory markers in women with multiple sclerosis.
  2. Gait and balance in people with Benign Paroxysmal Positional Vertigo (BPPV).
  3. Energy cost and kinematics of uphill and downhill walking in people with multiple sclerosis.
  4. The effect of a combined aerobic and strength exercise program in amyotrophic lateral sclerosis patients.
  5. Performance on the instrumented Timed Up and Go test in people with multiple sclerosis.

 

 

Outi Bat-El

Research topic: Typical and atypical language development – phonology and morphology

Research methods:

  • Data are drawn from longitudinal assessment of natural speech – one hour weekly sessions, from age 1 to 3 years old.
  • Data analysis is conducted with CPA – Child Phonology Analyzer (https://chengafni.wordpress.com/cpa/)

Projects in the lab include: Inter-child variation in the phonological development of Hebrew acquiring twins

Leitner Yael

Research topic:

Neurodevelopmental outcome of at-risk newborns/children

ADHA

Nir Sochen

Research topic:

  • Neuronal connectivity
  • Brain tissue characterization

Research  methods:

  • Diffusion MRI
  • Global characters of complex network of diffusion exchanges

Projects in the lab include:

  • The stochastic origin of diffusion MRI equations and corrections thereoff
  • Fingerprinting methods for simultaneous T1, T2 and diffusion restauration
  • Thermodynamic limit of the intricate structure of diffusion exchange in the millimeter scale in the brain

Liat Ben-Sira (Beinart)

Research topic:

  • Fetal M.R.I.
  • Brain malformation-neuro-development follow-up

Joint projects with other Faculty members in the Sagol School of Neuroscience:

  • Prof. Dafna Ben-Bashat
  • Prof. Yaniv Assaf

Shein-Idelson Mark

Research topic:
• Organization of population dynamics and coding across brain states.
• Evolution of neuronal computation.

Research methods:
• In-vivo and in-vitro large-scale, high-density extracellular electrophysiology.
• Signal processing and data analysis
• Computational modelling
• Intra-cellular electrophysiology

Projects in the lab include:
• Visual processing in the ancestral three layered cortex of turtles.
• Mechanistic sources of neuronal variability and their impact on coding.
• Organization of neuronal activity during interaction between oscillating sub-populations.
• Continuous monitoring and processing of 3D posture information in reptiles.
• Evolution of cortical computation – investigation of the amphibian dorsal pallium.